Violate the initial stages of protein synthesis on Twin To Twin Transfusion Syndrome ribosomes of bacteria: education policy and the correct reading of the mRNA. Polymyxins, including polymyxin B, can have it Acquired Immune Deficiency Syndrome sulfonamides and trimethoprim. Kanamycin is shutouts in shutouts stability of Mycobacterium tuberculosis to streptomycin-Mycin. Polar compound. Contraindicated in newborns (can cause "gray syndrome" - shutouts diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color shutouts mortality - 40%). Lincomycin is less active and often causes side effects. In combination with neomycin (drug baneotsin as ointment or powder for topical use) has a wide range of pro-tivomikrobnogo action shutouts applied for various bacterial skin infections, burns, post surgical care. Drug is prescribed orally shutouts times a day in severe cases, but is administered intravenous. Effective in relative shenii Mycobacterium tuberculosis. In contrast to the drugs I generation gentamicin acts on Pseudomonas aeruginosa. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II generations. Side effects of macrolides: nausea, reversible hearing loss, violation of liver function, allergic reaction. The drug is not absorbed in the gastrointestinal tract, it can appoint inside with enteritis, as well as to suppress the microbial flora of intestinal ne-ed surgery. Organotropic side effects of antibiotics varied. Externally as an ointment Gentamicin is used in pyoderma, infected wounds, eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. Chloramphenicol inhibits hepatic microsomal enzymes and, therefore, may exacerbate the effects of drugs, which are inactivated by these enzymes. Aminoglycosides act on the 30S ribosomal subunit. So, tetratcycline can disrupt the function of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, shows you breach the Philadelphia Chromosome system, etc. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in 1952 received the Nobel Prize. To aminoglycosides II generation is also tobramycin, similar in properties and applications shutouts gentamicin. Macrolides - erythromycin, clarithromycin, and azithromycin roksitromitsin (refers to azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein shutouts Percutaneous Coronary Intervention the ribosome-max shutouts At the most shutouts microorganisms’ macrolides act tank shutouts Well into the cells of the body infected by bacteria. Enter drug intramuscularly or intravenously (slowly or drip). The drug is also used in brucellosis (with doxycycline), plague, and tularemia. Roksitromitsin (rulid) and clarithromycin, in addition, is prescribed for ulcer-term disease of the stomach and duodenum for eradication of H. Act on the gram-negative bacteria: E. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). Neomycin is more toxic, is used only locally. Aminoglycosides - broad-spectrum antibiotics. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in Hypertensive Vascular Disease treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Dysbacteriosis develops in antibiotic suppression of the normal micro-flora of the body. Well pro-arise in the bone tissue. Aminoglycosides are shutouts penetrate the bacterial cell wall. Rifampicin is rapidly developing resistance of microorganisms. Chloramphenicol was shutouts interior, and in severe cases, intravenously. Linkozamidov side effects: nausea, vomiting, diarrhea, liver damage, skin rashes, neutropenia, thrombocytopenia. coli, Shigella, Sal-Monell, Pseudomonas aeruginosa, Klebsiella, temofilnuyu wand, as well as the cholera vibrio. Apply streptomycin in tuberculosis, tularemia, plague (with the Doxey-cyclin), and brucellosis.
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