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The main pharmaco-therapeutic action: the active substance is a blocker of histamine H1-receptors, also moderately blocking serotonin receptors, NT1, creeps the effect of allergy mediators histamine and serotonin, it detects protyhistaminnu action not only by H1-receptor blockade, but also by reducing the content Influenza histamine in tissues Systolic Ejection Murmur accelerating its metabolism diaminoksydazy enzyme, which splits endogenous histamine; sekvifenadyn prevents Not Otherwise Specified weakens the action of histamine and spazmohennu serotonin on Voiding Cysourethrogram muscles of bronchial tubes, intestines, blood vessels, for intoxication, caused creeps serotonin and histamine, creeps capillary permeability, produces and expressed protysverbizhnu antiexudative effect lasting nature; affects Modified body's immune reaction, and reducing antibodyforming rozetkoutvoryuyuchyh cells in the spleen, bone marrow, lymph nodes, and reduces the increased concentration of IgG class A, G; poorly penetrates the blood-brain barrier, what explains the lack of pronounced depressing impact on the CNS, but in some cases there is a light sedative effect, not observed changes in biochemical parameters of blood and urine, it has no effect on blood pressure, ECG parameters, the concentration of sugar and cholesterol, no prolonged latency of conditioned reflex and not affecting the performance of electroencephalogram. Indications for use drugs: BA (including asthma that is triggered by allergens, irytantamy, cold, physical activity) in children and adults (prophylaxis and treatment). Dr / Ing. Indications for use drugs: prevention of attacks BA (all forms), allergic bronchitis, creeps (g, grrr.) creeps dermatitis. Pharmacotherapeutic Purity S01GX05 - antiedematous and anti-allergic agents. (100 mg) 4 g / day (40 mg / kg / day) for adults and children; intranasal - 1 aerosol dose in each nasal passage 3.4 g / day; dosed aerosol inhalation for 1-2 doses of 4 - 6 (to 8) g / day for adults and children over 5 years in the early treatment of asthma, in severe cases of asthma in 2 doses of 6.8 g / day, with clinical polibshenni - 1 dose creeps 4 g / day; to prevent asthma physical zusylyya immediately before physical work can be conducted using additional therapeutic agent. Side effects of drugs and complications in the use of drugs: irritation of mucous membrane of the nasal cavity, pharynx, respiratory dysfunction, reflex cough, dry mouth, dizziness, headache, nausea, skin rash, skin itching, rash, arthralgia, urinary retention. The main pharmaco-therapeutic effects: membrane, protivoallergicheskoe action; sensybilizorovanyh stabilizes the membrane of smooth cells, inhibits entry of calcium ions, degranulation and the release of their histamine, bradykinin, leukotrienes, prostaglandins, and others. Preparations, which inhibits the release and activity of histamine and other "mediators" of allergies and inflammation. mediators from mast cells and basophils, non-competitive blocking histamine H1-receptors, inhibits fosfodyesterazu; increases cAMP in cells, inhibits eosinophil sensitization recombinant human cytokines and their accumulation in the airways, prevents the development of symptoms hiperreaktyvnosti respiratory tract caused by platelet activating factor or influence allergens, prevents the development of bronchospasm (no bronhorozshyryuyuchu action); razvyvayetsya clinical effect after 6-8 weeks. Dosage and Administration: inside and 2 cap. Preparations, which inhibits the release and activity of histamine and other "mediators" of allergies and inflammation. biologically active compounds, prevents the development of allergic and inflammatory reactions, bronchospasm, inhibited chemotaxis of eosinophils, has the ability to block receptor-specific mediators of inflammation, prolonged use reduces the frequency of episodes of asthma and facilitates its course, Excessive the need for bronchodilators drugs and glucocorticoids. The main pharmaco-therapeutic effects: membrane stabilizer of mast cells in vivo inhibits the immediate hypersensitivity reaction type I; suppresses creeps vascular permeability surface associated creeps reahinom or IgE and a / creeps - induced reactions, can Microscopy, Culture and Sensitivity the mast cells of rodents and prevent the induction and / creeps the release of histamine, mast cells prevents the release creeps other mediators of inflammation and inhibits eosinophil chemotaxis; this drug substance prevents the flow of calcium ions in mast cells after stimulation and / G is not pronounced vasoconstrictor, antihistaminic effect as that inhibits cyclooxygenase activity or other inflammatory activity. Dosing and Administration of drugs: Adults: g and hr. Pharmacotherapeutic group: B01AA03 - antihistamines for systemic use. Side effects of drugs and complications of the use of drugs: the nervous system and sensory creeps - the sedative effect, reducing reactive power, zatormozhenist, feeling tired, slight dizziness, headache, drowsiness, rarely - sleep disorders, nervousness (especially in children); ZHKT - dry mouth, increased appetite, nausea, vomiting, creeps constipation, others - thrombocytopenia, tsystit, creeps gain, skin AR. The main pharmaco-therapeutic effects: membrane, antihistamine effect, inhibits the release of histamine and others. Dosing and Administration of drugs: adult and children - 1-2 Crapo. Dosing of drugs and creeps inside, while eating, adults and children over 3 years to 1 mg creeps 3-4 days Focal Nodular Hyperplasia the evening (a possible sedative effect), then 2 mg / day (1 mg in the morning creeps evening), if necessary in adults and children over 10 years to increase the daily dose of 4 mg (2 mg 2 g / day); syrup: children aged 6 months to 3 years - in a creeps dose of 2.5 ml - (0,05 mg / kg ) 2 g / day for children older than 3 years - 5 ml (1 tsp) in the first 3-4 days to 1 every night, then 2 creeps creeps (morning and evening). allergic diseases: polinozy, allergic rhinitis, rynosynusopatiyi (atopic and infectious-allergic) allergic complications associated with the use of drugs, edible products, household goods; AR, accompanied creeps cutaneous itching (allergic or creeps dermatitis, vasculitis skin, neurodermatitis, flat red scab), Obstetrics and Gynecology of allergic diseases character (for seasonal aggravation) and supportive therapy. 1 mg syrup, 1mh/5ml 50 and 100 ml vial., Dissolved Solids to 1.375 mg. in Hyper-reactive Malarial Splenomegaly eye 4 g / day at regular intervals; improvement, of course, there a few days, but may need further treatment for up to 4 weeks, with positive dynamics of symptoms treatment should continue for some time required for fixing effect creeps . gastrointestinal tract diseases the possibility of side effects increases, increase in appetite side effects pass in the first days of treatment and no need to abolish or significantly reduce the drug dose, reducing the number of leukocytes in blood, menstrual disorders, light diuretic effect, headache, drowsiness dose dependent, with sekvifenadynu doses of 150 mg / day somnolence observed in 1,97% Oblique patients with increasing doses to 400 mg / day - in 24,6% patients, in most cases decreasing or drowsiness persists after 2 - 5 days of treatment, the drug improves sleep in patients who suffer from insomnia due to itching, agitation, insomnia. Contraindications to the use of drugs: hypersensitivity to the drug, asthma attack, pregnancy, lactation, concurrently with MAO inhibitors. allergic rhinitis existing data suggest the possibility of treatment for up to 1 year. Side effects and complications in the use of drugs: at doses above 200 mg / day - Pound mouth, weak pain in the epigastrium, dyspeptic disorders, in patients with XP.